Elevated brain lactate measured by H-MRS is an early phenotype due to mitochondrial dysfunction in the prematurely ageing mtDNA mutator mouse
نویسندگان
چکیده
J. M. Ross, J. Öberg, S. Brené, G. Coppotelli, M. Terzioglu, K. Pernold, R. Sitnikov, J. Kehr, A. Trifunovic, N-G. Larsson, B. J. Hoffer, and L. Olson Neuroscience, Karolinska Institutet, Stockholm, Sweden, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, United States, Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden, Neurobiology, Health Sciences and Society, Karolinska Institutet, Stockholm, Sweden, Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden, Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden, Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden, Max Planck Institute for Biology of Ageing, Cologne, Germany
منابع مشابه
High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio.
At present, there are few means to track symptomatic stages of CNS aging. Thus, although metabolic changes are implicated in mtDNA mutation-driven aging, the manifestations remain unclear. Here, we used normally aging and prematurely aging mtDNA mutator mice to establish a molecular link between mitochondrial dysfunction and abnormal metabolism in the aging process. Using proton magnetic resona...
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